\u73fe\u5728\u5c3f\u9178\u3092\u4e0b\u3052\u308b\u306b\u306f\u98df\u4e8b\u3001\u6c34\u5206\u6442\u53d6\u306a\u3069\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u304c\u3001\u5185\u670d\u85ac\u306b\u3064\u3044\u3066\u79c1\u306a\u308a\u306b\u8aac\u660e\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n
\u73fe\u5728\u3001\u6614\u304b\u3089\u3042\u308b\u30d5\u30a7\u30d6\u30ea\u30af\u3001\u3068\u3001\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\uff08\u30a6\u30ea\u30a2\u30c7\u30c3\u30af\uff09\u304c\u4e3b\u306a\u85ac\u5264\u3067\u3059\u3002\u3000\u30e6\u30ea\u30b9\u3068\u3044\u3046\u85ac\u3082\u3042\u308a\u307e\u3059\u304c\u3001\uff12\u756a\u624b\u306e\u85ac\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059\uff08\u52b9\u679c\u3092\u793a\u3059\u5834\u6240\u304c\u9055\u3046\u304b\u3089\u3067\u3059\uff09<\/p>\n
\u3069\u3061\u3089\u3082\u3001Xanthine Oxidoreductase\uff08XOR\uff1a\u30ad\u30b5\u30f3\u30c1\u30f3\u30aa\u30ad\u30b7\u30ec\u30c0\u30af\u30bf\u30fc\u30bc\uff09\u3068\u3044\u3046\u9175\u7d20\u3092\u6291\u5236\u3057\u3001\u5c3f\u9178\u3092\u4e0b\u3052\u307e\u3059\u3002
\n\uff08\u9175\u7d20\u3068\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u9055\u3044\u3067\u3059\u304c\u3001\u9175\u7d20\u306f\u5bb6\u5ead\u306a\u3089\u539f\u6750\u6599\u3092\u5909\u66f4\u3059\u308b\u30df\u30ad\u30b5\u30fc\u3001\u30ec\u30bb\u30d7\u30bf\u30fc\u306f\u523a\u6fc0\u304c\u52a0\u308f\u3063\u3066\u7d30\u80de\u5185\u306b\u4f1d\u3048\u308b\u3001\u81ea\u52d5\u5f0f\u96fb\u5b50\u30ec\u30f3\u30b8\u306e\u30dc\u30bf\u30f3\u3000\u3068\u3044\u3046\u611f\u3058\u3067\u3059\uff09<\/p>\n
\u30d5\u30a7\u30d6\u30ea\u30af\u3068\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u306fXOR\u3092\u6291\u5236\u3057\u3066\u30d7\u30ea\u30f3\u4f53\u304c\u5c3f\u9178\u306b\u5909\u308f\u308b\u306e\u3092\u9632\u3050\u85ac\u5264\u3067\u3059\u3002\u3000\u5927\u304d\u306a\u9055\u3044\u306f\u30d5\u30a7\u30d6\u30ea\u30af\u306f\uff11\u65e5\uff11\u56de\u3001\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u306f\uff11\u65e5\uff12\u56de\u3068\u3044\u3046\u9055\u3044\u3067\u3059\u3002<\/p>\n
\u3053\u308c\u306f\u3069\u3061\u3089\u3082\u8840\u4e2d\u5185\u3067\u5c11\u306a\u304f\u306a\u308b\u6642\u9593\u306f\u540c\u3058\u3067\u3059\u304c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3066\u3088\u308a\u9577\u304f\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u306e\u304c\u30d5\u30a7\u30d6\u30ea\u30af\u3067\u3059\u304c\u3001XOR\u306b\u5bfe\u3057\u3066\u306e\u7d50\u5408\u306f\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u306e\u65b9\u304c\u5f37\u3044\u3001\u3068\u3044\u3046\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u3000\u5c3f\u9178\u3092\u4e0b\u3052\u308b\u52b9\u679c\u306f\u307b\u307c\u540c\u3058\u3067\u3059\u304c\u3001\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u306f\u9ad8\u5bb9\u91cf\u3067\u814e\u81d3\u304b\u3089\u3067\u308b\u86cb\u767d\u3092\u6e1b\u3089\u3059\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Efficacy of topiroxostat on albuminuria in hyperuricemic patients with diabetic nephropathy (ETUDE study): a randomized, double-blind, placebo-controlled trial. 2014\u5e74\uff09\u3000\u307e\u305f\u52d5\u8108\u786c\u5316\u3092\u4e88\u9632\u3059\u308b\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u57fa\u790e\u7814\u7a76\u3067\u306fEffects of Xanthine Oxidoreductase Inhibitors on Reactive Oxygen Species Produced In Vitro from Xanthine Oxidase. 2019.\u3000\u3068\u3000\u5b9f\u969b\u306e\u4eba\u9593\u306e\u30c7\u30fc\u30bf\u3067\u306f\u3001The Effects of Topiroxostat, a Selective Xanthine Oxidoreductase Inhibitor, on Arterial Stiffness in Hyperuricemic Patients with Liver Dysfunction: A Sub-Analysis of the BEYOND-UA Study .2022\uff09
\n\u3053\u308c\u306f\u30d5\u30a7\u30d6\u30ea\u30af\u306b\u306f\u306a\u3044\u52b9\u679c\u3067\u3059\u3002\u3000\u3057\u304b\u3057\u30d5\u30a7\u30d6\u30ea\u30af\u306f\uff11\u65e5\u4e00\u56de\u306724\u6642\u9593\u5f8c\u306eXOR\u3068\u306e\u7d50\u5408\u7387\u304c\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u3088\u308a\u3082\u9ad8\u3044\u3001\u3068\u3044\u3046\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n
\u3053\u306e\u3088\u3046\u306a\u9055\u3044\u306f\u3001XOR\u306b\u5bfe\u3059\u308b\u4e21\u8005\u306e\u7d50\u5408\u306e\u9055\u3044\u304b\u3089\u751f\u3058\u308b\u3082\u306e\u3060\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3000\u3082\u306e\u3059\u3054\u304f\u565b\u307f\u7815\u3044\u3066\u8a00\u3046\u3068\u3001\u30d5\u30a7\u30d6\u30ea\u30af\u306f\u3000\u30de\u30b0\u30cd\u30c3\u30c8\u30b7\u30fc\u30c8\u3001\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u306f\u5f37\u529b\u306a\u30b9\u30c6\u30c3\u30ab\u30fc\u3000\u3068\u8a00\u3046\u9055\u3044\u3067\u3059\u3002\u300024\u6642\u9593\u7d4c\u3063\u305f\u6642\u306b\u3001\u30d5\u30a7\u30d6\u30ea\u30af\u306f\u78c1\u77f3\u3067\u7de9\u304f\u304f\u3063\u3064\u3044\u3066\u3044\u308b\u306e\u3067\u3001\u5c11\u3057\u3057\u304b\u5265\u304c\u308c\u306a\u3044\u3002\u3000\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u306f\u5f37\u529b\u306b\u304f\u3063\u3064\u304f\u3051\u3069\u3082\u3001\u5265\u304c\u308c\u308b\u3068\u3082\u3046\u4e00\u5ea6\u5f35\u308a\u4ed8\u304d\u306b\u304f\u3044\u3001\u3068\u8a00\u3046\u4f8b\u3048\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n
\u7406\u8ad6\u4e0a\u306f\u5c3f\u9178\u304c\u4f4e\u304f\u5b89\u5b9a\u3057\u3066\u3044\u308b\u4eba\u306b\u306f\u52d5\u8108\u786c\u5316\u4e88\u9632\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u304c\u3044\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u73fe\u5728\u306e\u3068\u3053\u308d\uff11\u65e5\uff11\u56de\u3067\u306e\u7814\u7a76\u304c\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u9006\u306b\uff11\u65e5\uff11\u56de\u3067\u4e0d\u5229\u76ca\u3092\u88ab\u308b\u7d50\u679c\u3082\u51fa\u3066\u3044\u307e\u305b\u3093\u3002\u4eca\u5f8c\uff11\u65e5\uff11\u56de\u3067\u5c3f\u9178\u304c\u4f4e\u5024\u5b89\u5b9a\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u52d5\u8108\u786c\u5316\u4e88\u9632\u304c\u7406\u8ad6\u4e0a\u3067\u306f\u306a\u304f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3057\u3066\u78ba\u7acb\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\uff09\u3000\u3000\u30d5\u30a7\u30d6\u30ea\u30af\u306f\u4f55\u305b\uff11\u65e5\uff11\u56de\u3067\u5c3f\u9178\u5024\u3092\u5341\u5206\u4e0b\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u3068\u8a00\u3046\u98f2\u307f\u5fd8\u308c\u306a\u3069\u306e\u7169\u96d1\u3055\u304c\u306a\u3044\u3053\u3068\u304c\u3044\u3044\u9762\u3067\u3059\u3002<\/p>\n
\u3059\u3067\u306b\uff11\u65e5\uff12\u56de\u306e\u85ac\u3092\u98f2\u3093\u3067\u3044\u3066\u3001\u52d5\u8108\u786c\u5316\u304c\u5f37\u3044\u60a3\u8005\u3055\u3093\u306b\u306f\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\u3002\u3000\u98f2\u307f\u5fd8\u308c\u304c\u591a\u3044\u65b9\u3084\u5c3f\u9178\u5024\u304c\u9ad8\u3044\u65b9\u306b\u306f\u5373\u52b9\u6027\u304c\u3042\u308b\u30d5\u30a7\u30d6\u30ea\u30af\u3002\u3000\u3068\u3044\u3063\u305f\u4f7f\u3044\u5206\u3051\u3082\u4e00\u3064\u306e\u624b\u6bb5\u3067\u3059\u3002<\/p>\n
\uff08\u5f53\u9662\u306e\u30d6\u30ed\u30b0\u306f\u8ee2\u7528\u7981\u6b62\u3067\u3059\uff09<\/p>\n
#\u5c3f\u9178\u3000#\u52d5\u8108\u786c\u5316<\/p>\n","protected":false},"excerpt":{"rendered":"
\u73fe\u5728\u5c3f\u9178\u3092\u4e0b\u3052\u308b\u306b\u306f\u98df\u4e8b\u3001\u6c34\u5206\u6442\u53d6\u306a\u3069\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u304c\u3001\u5185\u670d\u85ac\u306b\u3064\u3044\u3066\u79c1\u306a\u308a\u306b\u8aac\u660e\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002 \u73fe\u5728\u3001\u6614\u304b\u3089\u3042\u308b\u30d5\u30a7\u30d6\u30ea\u30af\u3001\u3068\u3001\u30c8\u30d4\u30ed\u30ea\u30c3\u30af\uff08\u30a6\u30ea\u30a2\u30c7\u30c3\u30af\uff09\u304c\u4e3b\u306a\u85ac\u5264\u3067\u3059\u3002\u3000\u30e6\u30ea\u30b9\u3068\u3044\u3046\u85ac\u3082\u3042\u308a\u307e\u3059\u304c\u3001\uff12…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1],"tags":[],"class_list":["post-3441","post","type-post","status-publish","format-standard","hentry","category-diseases4-2","category-blog"],"_links":{"self":[{"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/posts\/3441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/comments?post=3441"}],"version-history":[{"count":5,"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/posts\/3441\/revisions"}],"predecessor-version":[{"id":3448,"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/posts\/3441\/revisions\/3448"}],"wp:attachment":[{"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/media?parent=3441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/categories?post=3441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ikkukizunacl.com\/article\/wp-json\/wp\/v2\/tags?post=3441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}